The correlation between COX-2 as well as VEGF and adenomyosis

WANG Jiamei; XIAO Shulan

doi:10.3969/j.issn.1002-7386.2016.22.005

Abstract：Objective To investigate the expression and clinical significance of cyclooxygenase-2 ( COX-2 ) and vascular endothelial growth factor ( VEGF ) in endometrium of patients with adenomyosis.Methods The 44 cases of adenomyosis specimens identified by pathological examination were served as observation group,and the other 29 cases of non-adenomyosis specimens were served as control group.The expression levels of of COX-2 and VEGF in situ and ectopic endometrium were detected by immunohistochemisty.Results The positive expression rates of COX-2 protein in situ and ectopic endometrium at proliferative phase and secretory phase in observation group were 40.00%and 57.89%,88.00%and 94.74%,respectively,which were significantly higher than those in control group ( P <0.05).The positive expression rate of COX-2 protein in ectopic endometrium was significantly higher than that in situ endometrium ( P <0.05).The positive expression rates of VEGF protein in situ and ectopic endometrium at proliferative phase and secretory phase in observation group were 44.00%and 92.00%,73.68%and 100.00%,respectively, which were significantly higher than those in control group ( P <0.05).The positive expression rate of VEGF protein in ectopic endometrium was significantly higher than that in situ endometrium ( P <0.05).The expressions of COX-2 and VEGF in ectopic endometrium were positicely correlated to those in situ endometrium ( r =0.700 and 0.350,respectively, P <0.05).Conclusion The high-expressions of COX-2 and VEGF exist in ectopic endometrium of patients with adenomyosis,moreover, there is a positive correlation between them, which may be related with the pathogenesis and development of adenomyosis.