Effects of Danhong injection on serum levels of IL-6,PGE2,CRP in patients with lubar intervertebral disc protrusion after diskoscope minimally invasive surgery
Abstract：Objective To observe the effects of Danhong injection on serum levels of interleukin-6 ( IL-6 ) , prostaglandin E2 (PGE2) and C-reactive protein (CRP) in patients with lubar intervertebral disc protrusion after diskoscope minimally invasive surgery.Methods Eighty patients with lubar intervertebral disc protrusion pneumonia who were admitted and treated in our hospital from January 2011 to December 2014 were randomly divided into control group and observation group,with 40 patients in each group.The patients in both groups underwent diskoscope minimally invasive surgery, after operation the patients in control group were treated by conventional therapy,however,the patients in observation group,on the basis of control group, were treated by Danhong intravenous injection.The peripheral blood specimens were collected before operation and on 1d,4d,7d after operation,and the serum levels of IL-6,PGE2,CRP were detected and compared between two groups.Results Before operation there were no significant differences in the serum levels of IL-6,PGE2,CRP between two groups ( P >0.05).The levels of IL-6 on 4d after operation in observation group reached the minimum value,as compared with those in control group ( P <0.05).There were significant differences in the serum levels of PGE2 only on 7d after operation between two groups ( P <0.05) .The levels of CRP in both groups were decreased on 4d,7d after operation at some extent,however,which were significantly decreased on 7d after operation ( P <0.05).Conclusion Danhong injection is superior to control group in improvement of the levels IL-6, PGE2 and CRP,which provides an experimental basis for TCM pharmacology and establishes a foundation for clinical application.
Keywords：Danhong injectionlubar intervertebral disc protrusiondiskoscope minimally invasive surgeryinterleukin-6prostaglandin-2C-reactive protein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3092-3094 )