Therapeutic effects of puerarin combined with insulin aspart on gestational diabetes mellitus and their effects on pregnancy outcome

doi:10.3969/j.issn.1002-7386.2016.20.010

Abstract：Objective To observe the therapeutic effects of puerarin combined with insulin aspart on gestational diabetes mellitus ( GDM) and their effects on pregnancy outcome.Methods A total of 100 patients with GDM who were admitted and treated in our hospital from January 2013 to December 2015 were randomly divided into observation group ( n =50) and control group ( n =50).The patients in control group were treated by insulin aspart,however,the patients in observation group were treated by puerarin combined with insulin aspart.After treatment,the clinical curative effects,the levels of fasting blood glucose (FBG), 2 hour postprandial blood glucose (2hPBG), glycosylated hemoglobin (HbA1C), nighttime blood glucose, total cholesterol (TC), trigalloyl glycerol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol ( LDL-C) , cystatin C ( Cys C) and homocysteine ( HCY) were detected in both groups.Moreover the pregnancy outcomes of patients with GMD and complications of neonates at perinatal period were observed and compared between two groups.Results After treatment, the levels of FBG, 2hPBG, HbA1C, nighttime blood glucose,TC,TG,Cys C, HCY were significantly decreased in both groups, however,the levels of HDL-C were significantly increased, as compared with those before treatment.Moreover the improvement degree of these indexes mentioned above in observation group was superior to that in control group ( P <0.05).The incidence rates of bad pregnancy outcome and complications of neonates in observation group were significantly lower than those in control group, and the satisfactory degree in observation group was significantly higher than that in control group ( P <0.05).Conclusion The puerarin combined with insulin aspart can effectively decrease the levels of blood sugar, blood lipids of patients with GDM, and can reduce the incidence rates of maternal and infantile complications.