Effects of intravenous anesthesia combining with epidural anesthesia on hemodynamics and postoperative recovery in patients receiving laparoscopic cholecystectomy

doi:10.3969/j.issn.1002-7386.2016.20.008

Abstract：Objective To investigate the effects of intravenous anesthesia combined with epidural anesthesia on hemodynamics and postoperative recovery in patients receiving laparoscopic cholecystectomy.Methods One hundred and twenty-four patients who underwent laparoscopic cholecystectomy in our hospital from January 2014 to January 2015 were randomly divided into control group and trial group, with 62 patients in each group.The patients in control group received intravenous anesthesia,however,the patients in trial group received intravenous anesthesia combined with epidural anesthesia. The hemodynamic parameters in 5 time points were evaluated in both groups,and these parameters included heart rate ( HR) , systolic blood pressure (SBP) and diastolic blood pressure (DBP).The postoperative analepsia time, extubation time and leaving time from operating room were observed and compared between two groups. Moreover the incidence rates of postoperative nausea and vomiting, chills and bronchospasm were observed in both groups.Results When the patients entered operating room (T0) and on 60min after pneumoperitoneum (T4), there were no significant differences in HR levels between two groups ( P >0.05 ), however, during induction ( T1 ), pneumoperitoneum ( T2 ) and on 30min after pneumoperitoneum (T3), the HR levels in trial group were significantly lower than those in control group ( P <0.05).There were no significant differences in SBP levels in T0 and T4 between two groups ( P >0.05),however,the SBP levels in T1 in trial group were significantly higher than those in control group ( P <0.05),but the SBP levels in T2,T3 in trial group were significantly lower than those in control group ( P <0.05).There were no significant differences in DBP levels in T0 and T4 between two groups ( P >0.05), however,the DBP levels in T1,T2,T3 in trial group were significantly lower than those in control group ( P <0.05).There were no significant differences in postoperative analepsia time, extubation time and leaving time from operating room between two groups ( P >0.05),however, the numbers of patients who had nausea and vomiting, chills and bronchospasm in trial group were significantly less than those in control group ( P <0.05 ) .Conclusion The research results suggest that intravenous anesthesia combined with epidural anesthesia can effectively relieve the fluctuation of circulatory system in patients undergoing laparoscopic cholecystectomy, and can effectively avoid the occurrence of postoperative complications, moreover, which has no effects on postoperative recovery time,thus,which is worth using widely in clinical practice.