Comparison of clinical therapeutic effects between high-flux hemodialysis and conventional hemodialysis on renal insufficiency

DU Juan; TAN Feng

doi:10.3969/j.issn.1002-7386.2016.19.019

Abstract：Objective To compare the clinical therapeutic effects between high-flux hemodialysis and conventional hemodialysis on renal insufficiency,and to explore optimized dialysis method to treat renal insufficiency.Methods Sixty-four patients with renal insufficiency who were treated in our hospital from April 2013 to October 2014 were divided into observation group and control group according to different dialysis methods, with 32 patients in each group.The patients in observation group were treated by high -flux hemodialysis, however, the patients in control group were treated by conventional hemodialysis for three months.Before and after hemodialysis,the levels of blood urea nitrogen (BUN), blood creatinine (SCR), albumin ( ALb), and serum β2-M microspheres protein (β2-M), parathyroid hormone ( PTH) and serum electrolytes ( Na, K, CA, CL, P ) were detected, moreover, the adverse reactions after hemodialysis were observed and compared between two groups.Results After hemodialysis, the levels of Ur, Scr in both groups were significantly decreased, as compared with those before dialysis ( P <0.05), however,there were no significant differences between two groups ( P >0.05).After dialysis the serum levels of Alp in control group were obviously decreased,as compared with those before dialysis,but there were no significant differences in observation group before and after dialysis ( P >0.05) .Before dialysis, there were no significant differences in the levels of β2-M and PTH between two groups ( P >0.05),however,after dialysis there were significant differences between two groups ( P <0.05).After dialysis there were no significant differences in the levels of Na,K,P, Cl, as compared with those before dialysis in both groups ( P >0.05) ,the levels of Ca were increased,as compared with those before dialysis,but there were no significant differences between two groups ( P >0.05).The infection rate after dialysis in observation group was 18.75%,which in control group was 46.87%,there was a significant difference between two groups ( P <0.05) .Conclusion The high-flux hemodialysis has not only filtration effects,but also can decrease obviously the levels ofβ2-M and PTH, meanwhile, the infection rate after dialysis in observation group is lower than that in control group.The high-flux hemodialysis is superior to conventional hemodialysis in treatment of renal insufficiency,thus, which is worth spreading application in clinic.