Therapeutic effects of atomization inhalation on bronchial asthma in children and its effects on regulatory T cells and airway inflammation

ZHANG Yun; ZHANG Xiao; HUANG Zhihua

doi:10.3969/j.issn.1002-7386.2016.19.016

Abstract：Objective To observe the therapeutic effects of combination trigeminy atomization inhalation of budesonide (BUD), salbutamol (SAL) and ipratropium bromide (IB) on bronchial asthma in children and its effects on regulatory T cells and airway inflammation.Methods Forty children patients with bronchial asthma were randomly divided into two groups,with 20 patients in each group.The patients in observation group were treated by triple atomization inhalation of BUD,SAL and IB,however,the patients in control group were treated by oral Vitamin B1 (placebo),10mg/d.The srum levels of IFN-γand IL-4 in peripheral blood of patients were detected,the severity of bronchial asthma was evaluated according to asthma symptom scoring,and lung function was compared between two groups by FEV1 comparison method.The parameters about lung function were observed before treatment and on 1m,3m,6m after treatment for both groups.Moreover the pleural thickness and pleural sliding degree were detected after treatment.Results As compared with those in control group, the FEV1 was obviously improved,and the percentage of Th2 was significantly decreased in observation group ( P <0.05). Moreover the disbalance of Th1/Th2 and Treg/Th17 was significantly improved in observation group ( P <0.05).There were no significant differences in lung functions before treatment and on 1m,3m after treatment between two groups ( P >0.05). However the lung functions on 6m after treatment in observation group were superior to those in control group ( P <0.05). CT examination results showed that pleural thickness in observation group was thicker than that in control group,and pleural sliding degree in observation group was superior to that in control group ( P <0.05).Conclusion The atomization inhalation can balance cytokines again, regulate the balance of Th1/Th2 and Treg/Th17,improve lung function of patients,thus, which can relieve the symptoms of asthma.