Therapeutic effects of middle-late stage synchronism chemoradiation on cervical squamous cell carcinomas and influencing factors of distant metastasis

doi:10.3969/j.issn.1002-7386.2016.19.015

Abstract：Objective To observe the therapeutic effects of middle-late stage synchronism chemoradiation on cervical squamous cell carcinomas and influencing factors of distant metastasis.Methods The data about 139 patients with cervical squamous carcinoma ( stageⅡb ~Ⅳa ) who underwent middle-late stage synchronism chemoradiation in our hospital from October 2007 to October 2010 were retrospectively analyzed.The total survival rate, the survival rate in distant metastasis, the survival rate without metastasis were observed by the method of browse cases and telephone follow-up.The influencing factors of distant metastasis were investigated by single factor analysis and multiple factors analysis, respectively.Results Among 139 patients, there were 46 cases with relapse including 16 cases of local relapse, 23 cases of distant metastasis and 7 cases of local relapse combined with distant metastasis.Among 46 patients with relapse, 5 patients were survived,the other 41 patients died.However among 83 patients without relapse,only 10 patients died.The total survival rate in patients receiving middle-late stage synchronism chemoradiation was 63.30%,the survical rate in patients with distant metastasis was 3.57%, and the survival rate in patients without metastasis within 5 years was 89.24%.The results by single factor analysis showed that FIGO clinical staging,the levels of SCC-Ag after treatment,the levels of Hb before treatment, pelvic lymph node metastasis were the influencing factors on distant metastasis in patients receiving middle-late stage synchronism chemoradiation (χ2 =9.371, 11.245, 6.747, 5.110, respectively, P <0.01 or P <0.05).The results by multiple factors analysis showed that FIGO clinical staging,the levels of SCC-Ag after treatment, pelvic lymph node metastasis were independent influencing factors on distant metastasis in patients receiving middle-late stage synchronism chemoradiation (χ2 =2.412,4.536,3.553,respectively, P <0.05 or P <0.01).Conclusion The therapeutic effects of middle-late stage synchronism chemoradiation on cervical squamous cell carcinomas are better, and the total survival rate of patients is higher, thus, which is worth using widely in clinical practice.FIGO clinical stage, the levels of SCC Ag after treatment, pelvic lymph node metastasis are independent influencing factors on distant metastasis in patients receiving middle-late stage synchronism chemoradiation.