Inflammatory characteristics of colorectal mucous membrane under light microscope and correlation between the expressions of NF-κB, COX-2 and pathogenesis of colorectal cancer

WEN Changjiang; ZENG Qin

doi:10.3969/j.issn.1002-7386.2016.19.014

Abstract：Objective To observe the inflammatory characteristics of colorectal mucous membrane under light microscope,and to investigate the correlation between the expressions of nuclear factor (NF-κB), cyclooxygenase (COX-2) and pathogenesis of colorectal cancer.Methods Thirty patients with colorectal cancer,30 patients with colorectal adenoma who were admitted and treated in our hospital from July 2013 to July 2014 were enrolled in the study, moreover,the other 30 healthy subjects were served as control group.The tumor tissues and the normal tissues 5cm apart from tumor tissues were taken out as specimens,and the normal mucous membrane tissues were taken out in control group to be examined under light microscope for the lymph cell infiltration and gland morphous.Moreover the expression levels of NF-κB and COX-2 were detected and compared among three groups.Results The lymph cell infiltration degree in colorectal cancer, mucous membrane tissues beside cancer, rectal adenoma and adjacent tissues was significantly greater than that in normal mucous membrane tissues (P<0.05).The mutation rate of gland and mucous membrane beside colorectal cancer was significantly higher than that in adenoma adjacent mucous membrane and normal colon mucous membrane ( P <0.05).The expression levels of NF-κB and COX-2 in colorectal cancer and colorectal adenoma were significantly higher than those in normal mucous membrane ( P <0.05 ) .Conclusion The inflammatory manifestations exist in colorectal cancer, adenoma, colorectal mucous membrane,which are mainly gland mutant and lymphocyte infiltration.Moreover the expression levels of NF-κB,COX-2 in colorectal cancer and adenoma tissues are higher, which can provide reference for the diagnosis and treatment of the diseases.