Effects of Xuebijing injection on the levels of BNP, TnT and TnI in patients with severe sepsis and sepsis shock

GAO Li; YU Jianpeng; WANG Gangsheng

doi:10.3969/j.issn.1002-7386.2016.19.012

Abstract：Objective To observe the effects of Xuebijing on the levels of brain natriuretic peptide ( BNP ) , creatinine protein T ( TnT) and creatinine protein I ( TnI) in patients with severe sepsis and sepsis shock.Methods Seventy-eight patients with severe sepsis and sepsis shock who were admitted and treated in our hospital were divided into:trial group and control group,with 39 patients in each group.The patients in control group were treated by conventional treatment+09%sodium chloride solution 100ml, however, the patients in trial group were treated by conventional treatment+ Xuebijing injection .The levels of BNP, TnT, TnI and inflammatory cytokines before treatment and on 7 days after treatment were detected and compared between two groups.Results After treatment, the levels of BNP, TnT and TnI in trial group were significantly lower than those in control group[(484.32 ±24.03)ng/L vs (571.23 ±29.14)ng/L, (580.65 ±36.64)ng/L vs (657.53 ±43.24)ng/L,(543.53 ±41.03)ng/L vs (663.46 ±45.67)ng/L,respectively]( P <0.05).After treatment, the levels of tumor necrosis factor alpha (TNF-alpha),interleukin 6 (IL-6) and calcitonin (PCT) in trial group were significantly lower than those in control group[(38.43 ±3.21)pg/ml vs (53.54 ±4.05)pg/ml,(385.24 ±38.05)pg/ml vs (495.24 ± 45.78)pg/ml, (2.56 ±0.24)ng/ml vs (3.8 ±0.53)ng/ml, respectively]( P <0.05).Moreover the mechanical ventilation time and hospitalization time in trial group were significantly shorter than those in control group [ (7.43 ±0.87) d vs (9.53 ± 1.41)d, (12.35 ±1.34)d vs (18.95 ±1.87)d,respectively]( P <0.05).After 7-day treatment,the APACHEⅡscores in trial group were significantly lower than those in control group[(14.56 ±1.32) points vs (16.32 ±1.84)]( P <0.05). Conclusion Xuebijing injection can effectively decrease the levels of BNP, TnT and TnI in patients with severe sepsis and sepsis shock,with better therapeutic effects.