Clinical efficiency of single application of dezocine or combined with dexmedetomidine hydrochloride during general anesthesia surgery in children

WANG Weihua; QU Xiaowei

doi:10.3969/j.issn.1002-7386.2016.19.003

Abstract：Objective To observe the clinical efficiency of single application of dezocine or combined with dexmedetomidine hydrochloride ( DEX) during general anesthesia surgery in children.Methods One hundred and twenty-nine children patients who were scheduled for ophthalmologic operation under general anesthesia were randomly divided into 3 groups:combination medication group, single medication group and control group, with 43 patients in each group.Before anesthesia induction, the patients in combination medication group were given DEX by intravenous infusion,keeping it to the end of operation,however,the patients in single medication group and control group were given 0.9%sodium chloride solution by pump infusion,at 15min before end of operation,the patients in single medication group and combination medication group were given dezocine by pump infusion, but the patients in control group were given still 0.9% sodium chloride solution.The 10 time points were set up,which were before operation (T1),5min after pumping (T2), intubation instantly (T3), extubation instantly (T4), 5min after extubation (T5), 1h after operation (T6),2h after operation (T7),4h after operation (T8),6h after operation (T9),24h after operation (T10).The intraoperative and postoperative vital signs of patients, operation and analgesia status,serum levels of substance P (SP),concentrations of β-endorphin (β-EP), orphanin FQ ( OFQ) in the 10 time points and adverse reactions after 72 hours were observed and compared among the three groups. Results The levels of MAP, HR and dosage of sevoflurane in T3,T7 in combination medication group were significantly lower than those in the other two groups,however, the extubation time was significantly longer than that in the other two groups ( P<0.05).The restlessness scores and incidence rate of restlessness in combination medication group were significantly lower than those in the other two groups,moreover, the VAS scores in T6,T8 and FLACC scores in T6,T10 were significantly lower than those in control group, besides the FLACC scores in T6,T8 were significantly lower than those in single medication group (P<0.05).The sedation scores in T6 in combination medication group were significantly lower than those in the other two groups,moreover, the serum levels of SP,β-EP and OFQ after operation were also significantly lower than those in the other two groups ( P <0.05).Conclusion The dezocine combined with DEX is safe and effective in application during general anesthesia surgery in children,thus, which is worth using widely in clinical practice.