Expression and clinical significance of HER-2 and Ki-67 in colorectal cancer tissues

doi:10.3969/j.issn.1002-7386.2016.19.002

Abstract：Objective To investigate the expression and clinical significance of HER-2 and Ki-67 in colorectal cancer tissues.Methods Eighty patients with colorectal cancer who were admitted into our hospital from October 2013 to March 2015 were served as observation group,whose ablated colorectal cancer tissues were collected as specimens,and the other 20 healthy subjects were served as control group,whose intestine mucous membrane tissues were collected as specimens.The expression levels of HER-2 and Ki-67 were detected by immunohistochemistry ( SP) .Results The expression levels of HER-2 and Ki67 in observation group were significantly higher than those in control group ( P <0.05).The expression levels of HER-2 were not correlated to patient’s sex,age, lymph node metastasis, tumor’s location ( P >0.05),which were closely related with Dukes staging of colorectal cancer, cell differentiation degree, tumor's infiltration depth ( P <0.05).The expression levels of Ki-67 were not correlated to patient’s sex,age, tumor’s size and location, cell differentiation degree ( P >0.05),however, which were closely associated with tumor’s infiltration depth, lymph node metastasis and Dukes staging ( P <0.05).The expressions HER-2 were positively correlated to those of Ki-67( r =0.354, P <0.01).Conclusion The expressions of HER-2 and Ki-67 protein in colorectal cancer tissue are not correlated to patient’ s sex and age, tumor location, lymph node metastasis at some extent,however,which are closely related with cell differentiation of colorectal cancer tissue,Dukes staging, tumor’s infiltration depth.The expression levels of HER-2 and Ki-67 can be regarded as biological parameters for the diagnosis of colorectal cancer.