Effects of puerarin combined with insulin aspart on oxidative stress, insulin resistance and pancreatic β-cell function in pregnant women with gestational diabetes mellitus

HU Limei; JIANG Baohui; ZHANG Ying

doi:10.3969/j.issn.1002-7386.2016.18.011

Abstract：Objective To observe the effects of puerarin combined with insulin aspart on oxidative stress, insulin resistance and pancreatic β-cell function in pregnant women with gestational diabetes mellitus (GDM).Methods A total of 100 patients with GDM who were admitted and treated in our hospital from June 2013 to December 2015 were randomly divided into observation group ( n =50) and control group ( n =50).The patients in control group were treated by insulin aspart, however,the patients in observation group,on the basis of control group, were treated by puerarin combined with insulin aspart.After treatment,the levels of fasting blood glucose (FBG), 2 hours postprandial blood glucose (2hPBG), glycosylated hemoglobin (HbA1c), nighttime blood glucose, the activities of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), reactive oxygen species ( ROS), malondialdehyde ( MDA), fasting insulin ( FINS), homeostasis model HOMAβ-cell function index (HOMA-β), insulin resistance index (HOMA-IR), insulin sensitivity index (ISI), insulin secretion index (ΔI30 /ΔG30 ) and mixed insulin sensitivity (ISI comp) were detected and compared between two groups.Results After treatment, The levels of FBG,2 hPBG,HbA1c,ROS,MDA,FINS,HOMA-IR were significantly decreased,as compared with those before treatment in both groups,however the levels of GSH-IPX, SOD,HOMA-β,ISI,ΔI30 /ΔG30 and ISIcomp were significantly increased,as compared with those before treatment in both groups ( P <0.05).But the improvement degree of the indexes mentioned above in observation group was superior to that in control group ( P <0.05).Conclusion The puerarin combined with insulin aspart can effecetively decrease the levels of blood glucose in pregnant women with GDM,and can improve the disbalance of serum oxidation and antioxidative materials,moreover,which can improve insulin resistance and protect islet β-cell function.