Significance of E-selectin, heart-type fatty acid binding protein and ischemia-modified albumin in patients with AECOPD complicated by pulmonary embolism
WANG Mingjian
Abstract：Objective To observe the diagnostic value of E-selectin, heart type fatty acid binding protein (H-FABP),ischemia-modified albumin (IMA) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by pulmonary embolism (PE),and to explore their effects on patient’s prognosis.Methods Sixty-five patients with AECOPD complicated by PE who were admitted into our hospital from January 2012 to June 2015 were enrolled as PE group,including 25 cases of COPD Ⅱ grade,29 cases of COPD Ⅲ grade and 11 cases of COPD Ⅳ grade according to COPD classification.Furthermore these patients were divided into low-risk group ( n =18),medium-risk group (n =27) and high-risk group ( n =20) according to PE risk degree.The other 45 patients with AECOPD who were treated at the corresponding time period were enrolled as AECOPD group.Moreover 30 healthy subjects were enrolled as control group. The levels of E-selectin, IMA and H-FABP were detected and compared among the three groups.The correlation between the levels of E-selectin, IMA, H-FABP and COPD grading, PE severity, patient’ s prognosis was analyzed, furthermore, the correlation among E-selectin, IMA and H-FABP was also analyzed.Results The levels of E-selectin, IMA and H-FABP in AECOPD group and PE group were significantly higher than those in control group ( P <0.01),especially, the highest levels were found in PE group( P <0.01).The levels of E-selectin, IMA and H-FABP in PE group were increased with the increase of COPD degree and PE risk degree( P <0.01).The levels of E-selectin, IMA and H-FABP in death group of PE group were significantly higher than those in survival group of PE group( P <0.01).The levels of E-selectin were positively correlated to those of IMA( r =0.653, P <0.05) and H-FABP( r =0.753, P <0.05) in PE group, moreover, the levels of IMA were positively correlated to those of H-FABP( r =0.575, P <0.05).Conclusion E-selectin, IMA and H-FABP are involved in pathogenesis and development of AECOPD complicated by PE, which has important clinical value in evaluating the severity of disease and prognosis of patients with AECOPD complicated by PE.
Keywords：E-selectinfatty acid binding proteinischemia-modified albuminchronic obstructive pulmonary diseasepulmonary embolism
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2754-2757 )