Significance of IGF-1, HMGB-1, GSN and MIF in patients with hypertensive intracerebral hemorrhage

doi:10.3969/j.issn.1002-7386.2016.18.003

Abstract：Objective To investigate the significance of serum levels of insulin-like growth factor (IGF)-1, high mobility group box-1 protein (HMGB-1), gelsolin (GSN) and macrophage migration inhibitory factor (MIF) in patients with hypertensive intracerebral hemorrhage.Methods Seventy-eight patients with hypertensive intracerebral hemorrhage who were admitted and treated in our hospital from January 2013 to June 2015 were enrolled as hypertensive intracerebral hemorrhage group.These patients were divided into mild injury group ( n =17), moderate injury group ( n =36) and severe injury group ( n =25) according to the severity of nerve function injury,moreover, according to cerebral hemorrhage volume,the patients were divided into three groups: small hemorrhage group ( n =36), middle hemorrhage group ( n =27) and massive hemorrhage group ( n =15).In addition, according to Glasgow Outcome Scale these patients were divided into good prognosis group ( n =43) and poor prognosis group ( n =35).Besides the patients with simple intracerebral hemorrhage or simple hypertension who were treated in our hospital at the same period were divided into cerebral hemorrhage group ( n =45) and hypertension group ( n =35).The other 30 healthy subjects were served as control group.The serum levels of IGF-1,HMGB-1,GSN and MIF were detected in hypertensive intracerebral hemorrhage group,cerebral hemorrhage group,hypertension group and control group,and the correlation between the levels of IGF-1, HMGB-1, GSN MIF and neurologic impairment scores as well as cerebral hemorrhage area was analyzed, moreover the correlation between these indexes and patient’s prognosis and the correlation among the indexes were also analyzed.Results The levels of IGF-1 and GSN in hypertensive intracerebral hemorrhage group were significantly lower than those in cerebral hemorrhage, hypertension group and control group ( P <0.01), which in hypertension group or cerebral hemorrhage group were significantly lower than those in control group ( P <0.01).However the levels of HMGB-1 and MIF in hypertensive intracerebral hemorrhage group were significantly higher than those in cerebral hemorrhage group, hypertension group and control group ( P <0.01),which in hypertension group or cerebral hemorrhage group were significantly higher than those in control group ( P <0.01).The levels of GSN and IGF-1 levels in hypertensive intracerebral hemorrhage group were decreased with the increase of the severity of nervous lesion and cerebral hemorrhage area ( P <0.01).The levels of IGF-1 and GSN in good prognosis group were significantly higher than those in poor prognosis group ( P <0.01),but the levels of HMGB-1 and MIF were increased with the increase of the severity of nervous lesion and cerebral hemorrhage area ( P <0.01).The levels of HMGB-1 and MIF in good prognosis group were significantly lower than those in poor prognosis group ( P <0.01).Besides the levels of IGF-1 were negatively correlated to those of HMGB-1 ( r =0.457, P <0.05) and to MIF ( r =0.536, P <0.05), however,which were positively correlated to those of GSN ( r =0.754, P <0.05).The levels of HMGB-1 were negatively correlated to those of GSN ( r =0.486, P <0.05),however,which were positively correlated to those of MIF ( r =0.864, P <0.05), moreover, the GSN levels were negatively correlated to those of MIF ( r =0.758, P <0.05).Conclusion The IGF-1, HMGB-1, GSN and MIF are involved in the pathogenesis and development of hypertensive cerebral hemorrhage diseases, which play an important role in evaluating the severity and prognosis of hypertensive intracerebral hemorrhage.