Effects of intraoperative application of dexmedetomidine on hemodynamic indexes and analepsia quality at analepsia period during general anesthesia in patients receiving laparoscopic hysterectomy

doi:10.3969/j.issn.1002-7386.2016.17.012

Abstract：Objective To observe the effects of intraoperative application of dexmedetomidine on hemodynamic indexes and analepsia quality at analepsia period during general anesthesia in patients receiving laparoscopic hysterectomy. Methods Sixty patients who would receive laparoscopic hysterectomy under general anesthesia,with patient's age range being 43~60yr,body weight:45~77 kg, ASAⅠ~Ⅱ,were randomly divided into two groups. The 30 patients in dexmedetomidine group were given loading dose dexmedetomidine 0. 5μg/kg by pump infusion on 10min before anesthesia induction, then pumping continously maintenance dose dexmedetomidine 0. 2μg · kg-1 · h-1 until 40min before the end of operation, however,the 30 patients in control group were given same volume 0. 9% sodium chloride solution. The hemodynamic indexes including HR,SBP,MAP before anesthesia (T0), in extubation (T1), 10min after extubation (T2),were detected, moreover,the related indexes of analepsia quality including bucking, restlessness, shivering, residence time in postoperative recovery room were observed and compared between two groups. Results The intraoperative application of dexmedetomidine could obviously improve the analepsia quality in patients receiving laparoscopic hysterectomy. There were significant diffrences in the hemodynamic indexes including HR,SBP,MAP in T0,T1,T2 and the incidence rates of bucking, restlessness, shivering between dexmedetomidine group and control group ( P <0. 05), however, there was no significant difference in the residence time in postoperative recovery room between the two groups ( P >0. 05). Conclusion The application of dexmedetomidine in patients receiving laparoscopic hysterectomy has the advantages of fewer cardiovascular responses during extubation, more stable hemodynamic indexes, lower incidence rate of bucking, which can decrease effectively the incidence rates of postoperative restlessness and shiver, thus,which is a feasible scheme in clinical practice.