Changes of serum myocardium enzyme spectrum in patients with acute organophosphorus pesticide poisoning
Abstract：Objective To observe the changes of serum myocardium enzyme spectrum in patients with acute organophosphorus pesticide poisoning ( AOPP) . Methods The clinical data about 120 patients with AOPP were retrospectively analyzed. According to the severity of poisoning,these patients were divided into mild, moderate and severe poisoning groups. Moreover the 120 patients with AOPP were divided into toxic myocarditis group ( n =88 ) and non-toxic myocarditis group (n=32) according to clinical symptoms and signs, myocardium enzyme spectrum and ECG results. The serum levels of aspartate amino transferase (AST), lactate dehydrogenase (LDH), phosphocreatine kinase (CK), phosphocreatine kinase isoenzyme ( CKMB) and α-hydroxybutyrate dehydrogenase (α-HBDH ) ,cholinesterase activity and APACHEⅡscores were detected in all the groups. Besides the 60 healthy subjects were served as control group. Results As compared with those in control group, the serum levels of AST, LDH, CK, CKMB,α-HBDH in poisoning group were significantly increased, however, the levels of cholinesterase were significantly decreased ( P <0. 05). With the aggravation of poisoning degree,the serum levels of AST,LDH,CK,CKMB,α-HBDH and APACHEⅡscores were gradually increased,but cholinesterase activities were gradually decreased ( P <0. 05). The levels of AST,LDH,CK,CKMB,α-HBDH and APACHEⅡ scores in toxic myocarditis group were significantly increased, however, the cholinesterase activities were significantly decreased,as compared with those in non-toxic myocarditis group ( P <0. 05). Sperman correlation analysis showed that the levels of myocardium enzyme in patients with AOPP complicated by toxic myocarditis were positively correlated to the severity of poisoning and APACHEⅡ scores,however,which were negatively correlated to the cholinesterase activities ( P <0. 05). Conclusion The changes of serum myocardium enzyme spectrum are important serum markers to reflect the severity of AOPP,moreover, the serum myocardium enzyme spectrum is closely correlated to the severity of poisoning, cholinesterase activities and APACHEⅡscores in patients with AOPP complicated by toxic myocarditis.
Keywords：acute organophosphorus pesticide poisoningtoxic myocarditismyocardium enzyme spectrum
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2592-2594 )