The clinical efficiency of rosuvastatin on LVF and EDF in elderly patients with CHD
Abstract：Objective To observe the therapeutic effects of rosuvastatin on left ventricular function ( LVF ) and endothelium diastolic function (EDF) in elderly patients with coronary heart disease (CHD). Methods One hundred and sixty patients with cardiac insufficiency complicated by unstable angina who were treated in Heyang County Hospital were enrolled in the study. According to different antilipemic agents,the patients were divided into conventional therapy group and rosuvastatin group. The left ventricular ejection fraction (LVEF), left ventricular peak filling rate (LVPFR), endothelium-dependent diastolic function ( EDD) , non-endothelium-dependent diastolic function ( NEDD) were detected before treatment, on 3d,1w, 1m, 3m, 6m after treatment for both groups. Results The LVEF and LVPFR in rosuvastatin group on 1m, 3m, 6m after treatment were significantly higher than those in conventional therapy group,moreover, which were significantly higher than those before treatment ( P <0. 05). The EDD and NEDD in rosuvastatin group on 1m, 3m, 6m after treatment were significantly better than those in conventional therapy group,moreover, which were significantly better than those before treatment ( P <0. 05). Pearson correlation analysis showed that LVEF was positively correlated to EDD,NEDD ( r =0. 741,0. 736, respectively, P <0. 05). Conclusion Rosuvastatin can improve LVF and EDF of elderly patients with CHD at some extent.
Keywords：rosuvastatincoronary atherosclerosisleft ventricular functionendothelial diastolic function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2586-2588 )