Effects of different dose of propofol by intravenous anesthesia on neurological function of patients with acute severe craniocerebral injury after operation

doi:10.3969/j.issn.1002-7386.2016.17.006

Abstract：Objective To investigate the effects of different dose of propofol by intravenous anesthesia on neurological function of patients with acute severe craniocerebral injury after operation. Methods Eighty patients with acute severe craniocerebral injury who were admitted and treated in our hospital were enrolled in the study. According to random digits table these patients were divided into observation group and control group, with 40 patients in each group. The patients in both groups were given propofol for intravenous anesthesia,the drug dose in observation group was 4mg·kg-1 ·h-1 ,however, the dose in control group was 8mg·kg-1 ·h-1 . The changes of intracranial pressure and cerebral oxygen partial pressure were observed before anesthesia induction (T1), after trachea cannula (T2), after cerebral dura mater incision (T3),after 2-hour infusion (T4), at end of operation (T5) in both groups. The changes of levels of interleukin 1(IL-1), interleukin 6(IL-6), tumor necrosis factor-alpha ( TNF-α) , S100β100βwere observed and compared between two groups. Besides the neurological function status of patients after operation was observed. Results The intracranial pressure at T5 in observation group was obviously lower than that in control group,however, the cerebral oxygen partial pressure (16. 72 ± 4. 29) was significantly higher than that in control group ( P <0. 05). The levels of IL-1, TNF-α, IL-6 and S100βat T5 in observation group were, respectively, which were significantly lower than those in control group,respectively ( P <0. 05). After surgery, the total incidence of adverse neurological function in observation group was 5%, which was significantly lower than that ( 25%) in control group ( P <0. 05). Conclusion It is not suitable to apply propofol in a dose of 8mg·kg-1 ·h-1 for intravenous anesthesia in patients with acute severe craniocerebral injury, which may damage neurological function of patients, thus, 4mg·kg-1 ·h-1 dose of propofol should be applied to improve the recovery of neurological function of patients.