An experimental study of the effects of magnesium chloride on the renovation of sciatic nerve injury in rats
Abstract：Objective To investigate the effects of magnesium chloride on the renovation of sciatic nerve injury in rats.Methods Sixty SD rats were randomly divided into 3 groups, with 20 rats in each group.The rat models of sciatic nerve defect (1cm) were established by bridging sciatic nerve defect with silica gel tube to set up a nerve regeneration chamber ( NRC) .According to the different mediums that was infused into NRC , the rats were divided into 3 groups: magnesium chloride group (MgCl2 group),nerve growth factor group (NGF group) and physiological saline group (control group).The changes of lower limb ulcer and electromyogram on 1w, 2w, 4w, 8w after operation were observed respectively , moreover, the wet weight of musculus triceps surae was measured on 12w after operation.Results On 8w after operation, the muscular atrophy in NGF group and MgCl 2 group was recovered at some extent , the stiffness degree was decreased at some extent , and the extension angle of limbs and digiti pedis was increased , however , the muscular atrophy in muscle of posterior limb in control group was not obviously recovered .On 12 w after operation , the muscles of rats ’ hind legs in NGF group and MgCl 2 group were well stacked and the stiffness degree was decreased further ,however , the stiffness degree in control group was not obviously decreased.On 4w after operation,the recovery of nerve conductive velocity in experimental group was better than that in control group untill 12 weeks,as compared with that in control group ( P <0.05).On 12w after operation,the wet weight of musculus triceps surae in experimental group was significantly recovered ,as compared with that in control group in which the recovery speed in NGFgroup was the fastest ,but there was no significant difference between NGF group and MgCl 2 group ( P>0.05).Both MgCI2 and NGF could promote the repair process of nerve injury , there were no significant differences in all the indexes between MgCl2 and NGF,however,both of them were superior to control group .Conclusion Magnesium chloride is able to promote repairing of sciatic nerve injury in rats .
Keywords：magnesium chlorideneural restorationnerve growth factorsciatic nerve injury
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2440-2442,2446 )