Correlation between the levels of FeNO and inflammatory phenotype in patients with asthma
MEI Zhanqiang
HU Shaozhi
LUO Zhiyang
Abstract：Objective To investigate the correlation between the levels of exhaled nitric oxide ( FeNO ) and inflammatory phenotype in patients with asthma .Met hods One hundred patients with bronchial asthma ( asthma group ) who were admitted and treated in Department of Respiratory Medicine of our hospital and 80 healthy subjects ( control group ) were enrolled in the study .The levels of FeNO and serum inflammatory factors were detected and compared between two groups . Results The levels of ECP , IL-4, IL-6, IL-8, IL-13,TNF-α, FeNO in asthma group were significantly higher than those in control group ( P <0.05).However the levels of IL-2, IFN-γin asthma group were significantly lower than those in control group ( P<0.05).The levels of ECP, IL-4, IL-6, IL-8, IL-13,TNF-α,FeNO in patients with bronchial asthma at acute onset period were significantly higher than those of patients at remission period ( P <0.05).But the levels of IL-2,IFN-γin patients with bronchial asthma at acute onset period were significantly lower than those of patients at remission period ( P <0.05).The levels of ECP, IL-4, IL-6, IL-8, IL-13, TNF-αwere positively correlated to those of FeNO in asthma group (P<0.05).However the levels of IL-2, IFN-γwere negatively correlated to those of FeNO in patients with bronchial asthma (P<0.05).Conclusion The levels of FeNO and inflammatory indexes in patients with bronchial asthma are obviously increased , moreover ,the levels of FeNO are positively correlated with the severity and inflammation reaction degree in patients with bronchial asthma.
Keywords：bronchial asthmaexhaled nitric oxideinflammation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2422-2424 )