Therapeutic effects of rosuvastatin on coronary heart disease complicated by hyperlipidemia
CHENG Yanchun
Abstract：Objective To analyze the clinical efficacy of rosuvastatin in patients with coronary heart disease ( CHD) complicated by hyperlipidemia .Methods Two hundred patients with CHD complicated by hyperlipidemia who were treated in our hospital from June 2012 to June 2014 were randomly divided into trial group and control group ,with 100 patients in each group.The patients in control group were treated by Xuezhikang , however, the patients in trial group were treated by rosuvastatin .After 8-week treatment , the levels of total cholesterol ( TC) , low density lipoprotein cholesterol ( LDL-C) , high density lipoprotein ( HDL ) , highsensitivity C reactive protein ( hs-CRP ) , interleukin-6 ( IL-6 ) , nitric oxide ( NO ) , endothelin-1 (ET-1) and haemorheology indexes including high shear whole blood viscosity , plasma viscosity, fibrinogen, platelet aggregation rate were detected and compared between two groups .Results After treatment the levels of TG , TC, and LDL-C in trial group were significantly lower than those in control group ( P <0.05).The levels of hs-CRP, IL-6, ET-1 in trial group were significantly lower than those in control group , however , the levels of NO were significantly higher than those in control group ( P <0.05).The high shear whole blood viscosity ,plasma viscosity,fibrinogen and platelet aggregation rate in trial group were significantly lower than those in control group ( P <0.05).Conclusion As compared with Xuezhikang , rosuvastatin can effectively reduce the levels of blood lipids and inflammatory factors and can improve blood viscosity and endothelial function of patients with CHD complicated by hyperlipidemia .
Keywords：coronary heart diseasehyperlipidemiarosuvastatin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2419-2421 )