The incidence rate, distribution characteristics and related influencing factors of cadiovascular calcification in peritoneal dialysis patients

CHEN Guanfen; XIN Liqin; YANG Lihua

doi:10.3969/j.issn.1002-7386.2016.16.002

Abstract：Objective To evaluate the cardiac valve calcification and aortic arch calcification in peritoneal dialysis patients, and to analyze the incidence rate , distribution characteristics and related influencing factors of cadiovascular calcification.Methods One hundred and seventy -four patients who underwent peritoneal dialysis in our hospital were enrolled in the study.The patient’s blood pressure of brachial artery was measured in unification time point ,and blood urea nitrogen,creatinine values, 24-hour urine volume,dialysis liquid volume,urea nitrogen,creatinine and contents of urea nitrogen and creatinine in dialysis liquid were detected to evaluate the dialysis efficiency and residual renal function of patients .The biochemical indicators of patients were detected at an interval of 6 months, moreover, the patients received Doppler ultrasonography and chest X-ray examination,finally, the risk factors influencing cardiovascular calcification were evaluated by Logistics regression.Results The average age [(63 ±14)years],dialysis duration and serum levels of phosphorus in patients with aortic arch calcification and heart valve calcification were significantly higher than those of patients without calcification (P<0.05), and residual renal function values were significantly lower than those of of patients without calcification ( P <0.05).The incidence of cardiac valve calcification and aortic arch calcification was significantly increased along with the growth of patient’s age and dialysis duration ( P <0.05).The patient's age, dialysis duration and calcium-phosphorus product were independent risk factors influencing cardiac valve calcification ( P <0.05),in which, the danger coefficient of calcium-phosphorus product was the highest ,moreover, patient’ s age,dialysis duration and serum levels of phosphorus were independent risk factors influencing aortic arch calcification ( P <0.05),in which, the danger coefficient of serum levels of phosphorus was the highest ( P <0.05).Besides residual renal function of patients was independent risk factors influencing cardiac valve calcification and aortic arch calcification,furthermore,which was protection factor.Conclusion The patient’s age and dialysis duration are independent risk factors influencing cardiac valve calcification and aortic arch calcification.The calcium-phosphorus product is independent factor influencing cardiac valve calcification , with the highest danger coefficient , besides, the serum level of phosph is independent factor influencing aortic arch calcification , with the highest danger coefficient.