Therapeutic effects of Naoxintong capsule on cerebral infraciton complicated by myocardial ischemia-Multicenter nonrando mized controlled clinical trial

LI Ning; XU Qin; HUANG Yonghua

doi:10.3969/j.issn.1002-7386.2016.16.001

Abstract：Objective To observe the therapeutic effect of Naoxintong capsule on cerebral infarction complicated by myocardial ischemia . Methods The patients with acute cerebral infarction complicated by myocardial ischemia who were admitted and treated in Department of Neurology of 21 hospitals in Beijing from October 2013 to December 2014 were nonrandomly divided into Naoxintong group ( conventional therapy +Buchang Naoxintong capsules ) and control group ( conventional therapy only ) .The changes of electrocardiogram ECG were observed and compared between two groups , moreover, the changes of neurological function on the 4th week, the 8th week,the 12th week were analyzed by using NIHSS and modified mRankin . Results A total of 544 patients were enrolled in the study ,in whom 16 patients were excluded for some reasons,including 2 cases of adverse events , 1 case of automatic give up ,1 case of violation of rules ,6 cases of follow-up failure and 6 cases of the other reasons ,actually 528 cases were enrolled in the trial including 291 cases in Naoxintong group and 237 cases in control group .There was no significant difference in the effective rate of improving myocardial ischemia on the 4th week between two groups (18.1%vs 14.9%, P >0.05).However there were significant differences in the effective rates of improving myocardial ischemia on the 8th week and the 12th week between two groups (27.7%vs 14.3%,31.3%vs 16.9%,respectively, P <0.01).On the 12th week,the the proportion of decrease of NIHSS≥2 points was 77.7% in Naoxintong group,which was significantly higher than that (68.4%) in control group ( P <0.05),moreover, the proportion of decrease of mRankin≥1 point was 67.7% in Naoxintong group,which was significantly higher than that (56.1%) in control group ( P <0.05).Multiple-factor logistic regression analysis showed that Naoxintong capsule was independent influencing factor on the improvement of ECG ( P <0.01) and the decrease of AST on the 12th week (P <0.05).The influencing factors of improvement of neurological function included Naoxintong treatment , baseline systolic blood pressure , serum creatinine,previous history of heart disease or hyperlipidemia . Concluis on The therapeutic effects of Naoxintong on cerebral infarction complicated by myocardial ischemia are definited and satisfactory .