Effects of subclinical hypothyroidism in gestational period on blood glucose and blood lipid metabolism in pregnant women with gestational diabetes mellitus
HE Wenhui
LI Xianglan
WANG Xiaojing
Abstract：Objective To investigate the effects of subclinical hypothyroidism ( SCH) in gestational period on blood glucose and blood lipid metabolism in pregnant women with gestational diabetes mellitus ( GDM) .Methods One hundred and fifteen pregnant women with GDM complicated by SCH were enrolled as observation group ,and the other 110 pregnant women with simple GDM were served as control group .The levels of blood lipid and uric acid were detected ,and OGTT and C-peptide release test were performed and compared between two groups .Results The levels of TC , TG , LDL-C, uric acid in observation group were significantly higher than those in control group ( P <0.05),however,the levels of FPG,1hPBG, 2hPBG were significantly lower than those in control group ( P <0.05).The C-peptide release test showed that the levels of C-peptide in 0min(CP0),60min(CP1h),120min(CP2h) in observation group were significantly higher than those in control group ( P <0.05).The correlation analysis indicated that the levels of FPG ,1hPBG,2hPBG were negatively correlated to those of TSH ( r =0.489, 0.498, 0.504, respectively, P <0.01).The C-peptide release test showed that the levels of C-peptide in cp0,cp1,cp2 were positively correlated to those of TSH ( r =0.467, 0.432, 0.426,respectively, P <0.05). Conclusion The gestational diabetes mellitus complicated by SCH can enhance the levels of blood lipid of patients ,reduce the levels of blood glucose and increase the levels of C-peptide,moreover, along with the increase of TSH , the decrease of blood glucose and improvement of pancreatic islet function are more obvious .
Keywords：subclinical hypothyroidismgestational diabetes mellitusglucose metabolism
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2289-2291 )