Correlation between gene polymorphism of MTHFR and serum folate, homocysteine and in elderly patients with cardiovascular and cerebrovascular diseases
Abstract：Objective To investigate the correlation between gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) and serum folate and homocysteine (HCY) in elderly patients with cardiovascular and cerebrovascular diseases.Methods The gene polymorphism of MTHFR and serum levels of folate , homocysteine and Vitamin B12 were detected in 104 elderly patients with cardiovascular and cerebrovascular diseases , and the correlation between gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) and the serum levels of folate, homocysteine, Vitamin B12 was analyzed.Results The proportion of MTHFRC667 gene wild type (CC type), heterozygosis mutant type (CT type) and homozygosis mutant type ( TT type) was 20.19%, 36.5%, 43.3%, respectively.The proportion of CT/TT in case group was 38.5%,61.5%, respectively, which was significantly higher than that in control group. The levels of plasma HCY were negatively correlated to those of folate and Vitamin B12 ( P <0.05).The levels of folate and Vitamin B12 in TT type were significantly lower than those in CC type ( P <0.05),however,the plasma levels of HCY in TT type and CT type were significantly higher than those in CC type ( P <0.05).Conclusion MTHFR gene polymorphism in eiderly patients with cardiovascular and cerebrovascular diseases has a certain correlation with plasma HCY , moreover, which is negatively correlated to folate ,HCY and Vitamin B12.
Keywords：cardio-cerebrovascular diseasesMTHFR gene polymorphismfolatehomocysteine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2286-2288 )