Therapeutic effects of thymopetidum on pulmonary tuberculosis complicated by diabetes mellitus

doi:10.3969/j.issn.1002-7386.2016.15.012

Abstract：Objective To observe and evaluate the therapeutic effects of thymopetidum on pulmonary tuberculosis ( TB ) complicated by diabetes mellitus .Methods Ninety -two patients with TB complicated by diabetes mellitus were randomly divided into two groups:observation group and control group ,with 46 patients in each group .The patients in control group were treated by conventional anti-TB therapeutic schedule and hypoglycemics , however , the patients in observation group,on the basis of control group ,were given thymopetidum (2mg/d) by intravenous drip ,with a treatment course of 30 days for both groups.The changes of T lymphocyte subsets (CD3+,CD4+,CD8+) and IFN-γ,IL-10 were detected before treatment and after 1-month treatment ,moreover , the therapeutic effects were observed and compared between two groups .Results The sputum negative conversion rate , remission of pulmonary lesion and diminution or closure of pulmonary cavities in observation group were superior to those in control group , meanwhile,the levels of T lymphocyte subsets (CD3+,CD4+,CD4+/CD8+) were obviously increased, however, the levels of CD8+,IL-10 were significantly decreased in observation group (P <0.05). Conclusion The conventional anti -TB therapeutic schedule combined with thymopetidum can increase sputum negative conversion rate, promote remission of pulmonary lesion , enhance immunity of organism , moreover, which can increase the levels of IFN-γin peripheral blood,decrease the levels of IL-10 to recover the balance of Th1/Th2.