Comparison of therapeutic effects between surgery and conservative treatment on necrotizing enterocolitis in low birth weight neonates

doi:10.3969/j.issn.1002-7386.2016.15.010

Abstract：Objective To compare the therapeutic effects between surgery and conservative treatment on necrotizing enterocolitis in low birth weight neonates .Methods One hundred low birth weight neonates with necrotizing enterocolitis who were admitted and treated in our hospital from May 2013 to May 2015 were enrolled in the study .The neonates were divided into two groups:surgery treatment group ( n =50 ) and conservative treatment group ( n =50 ) .After treatment the clinical parameters, inflammatory factors levels and survival rates were compared between two groups ,moreover, the risk factors of affecting patient’s prognosis were analyzed.Results Before treatments, there were no significant differences in the clinical parameters including fecal occult blood test , platelet count, white blood cell count between two groups ( P >0.05).After treatment,the improvement status of these parameters mentioned above in surgery treatment group was superior to that in conservative treatment group ( P <0.05).Before treatments,there were no significant differences in the levels of inflammatory factors including IL-1β,TNF-α,IL-6,IL-10 between two groups ( P >0.05),however,after treatment of the levels of the inflammatory factors were significantly decreased in both groups , moreover , the decrease degree in surgery treatment group was more obvious than that in conservative treatment group ( P <0.05).The death rate in surgery treatment group was lower than that in conservative treatment group , and patient ’ s prognosis in surgery treatment group was much better than that in conservative treatment group .Logist regression analysis showed that the important factors of affecting patient ’ s prognosis were respiratory failure, renal dysfunction,intestinal perforation or peritonitis,WBC<5 ×109/L or>20 ×109/L,thrombocytopenia and diminished or disappeared bowel sounds .Conclusion Taking surgery treatment for low birth weight neonates with necrotizing enterocolitis can effectively improve intestinal tract function and related blood routine parameters , decrease the levels of inflammatory factors so us to enhance survival rate of neonates .Moreover the neonates with complications may have poor prognosis ,which suggests that these neonates should be treated by surgery as early as possible .