Clinical observation for the therapeutic effects of fasudil hydrochloride during cardiopulmonary bypass in patients receiving mitral valve replacement

doi:10.3969/j.issn.1002-7386.2016.15.004

Abstract：Objective To observe the therapeutic effects of fasudil hydrochloride during cardiopulmonary bypass (CPB) in patients receiving mitral valve replacement (MVR).Methods Forty patients who received MVR were randomly divided into two groups , trial group ( n =20 ) and control group ( n =20 ) .The patients in trial group were given fasudil (1mg/kg),however, the patients in control group were given equivalent 0.9%sodium chloride solution.The concentrations of LDH, CK-MB, cTnI and lactic acid in plasma were detected after anesthesia ( T1 ) and at 5 different time points after CPB (T2-T5), moreover, the clinical parameters were analyzed and compared between two groups .Results After CPB,the levels of LDH in trial group were significantly lower than those in control group in T 4,T5[(486.05 ±39.52)U/L vs (528.13 ± 47.65)U/L,(551.80 ±35.43)U/L vs (593.88 ±48.89)U/L, respectively, P <0.01].The levels of CK-MB in trial group were significantly lower than those in control group in T 3,T4,T5 [(78.39 ±8.27)U/L vs (88.68 ±16.18)U/L,(62.46 ± 6.10)U/L vs (72.37 ±11.85)U/L,(47.81 ±8.19)U/L vs (54.56 ±9.21)U/L,respectively, P <0.05 or P <0.01]. The levels cTnI in trial group were significantly lower than those in control group in T 3,T4,T5[(4.40 ±1.12)ng/ml vs (5.80 ±1.51) ng/ml,(4.93 ±1.23) ng/ml vs (6.49 ±1.62) ng/ml,(3.99 ±1.20) ng/ml vs (5.80 ±1.30) ng/ml, respectively, P <0.01].After CPB, the levels of lactic acid in trial group were significantly lower than those in control group ( P <0.05),however, postoperative breathing machine application time , the dosage of dopamine and ICU staying time in trial group were significantly lower than those in control group ( P <0.05 or P <0.01).Conclusion The fasudil hydrochloride can decrease the levels of LDH , CK-MB, cTnI and lactic acid in plasma of patients after receiving MVR ,and can improve cardiac function, promote the recovery of cardiac function ,relieve general inflammatory reactions ,shorten the length of staying in hospital after operation ,thus,which plays an important role in clinical treatment .