The significance of expression levels of serum cystatin C and urine protein markers in prognosis evaluation for patients with acute heart failure
CHEN Yunqi
LI Haili
Abstract：Objective To investigate the significance of expression levels of serum cystatin C (Cys-C),and urine protein markers in prognosis evaluation for patients with acute heart failure .Methods Ninety patients with acute heart failure who were admitted and treated in our hospitral from January 2014 to June 2015 were served as observation group ,and the other 90 healthy subjects were served as control group .The levels of Cys-C, brain natriuretic peptide ( BNP ) , serum creatinine (Scr),urea nitrogen,left ventricular ejection fraction (LVEF) were detected in both groups.Moreover the changes of Cys-C, Scr, urinary β2 microglobulin (β2-MG) and albumin ( Alb) on 24 hours after heart failure were observed and compared between two groups.Results The levels of Cys-C (1.77 ±0.62) in observation group were significantly higher than those (0.83 ±0.32) in control group ( P <0.05), moreover, which were gradually increased with the increase of cardiac function grade of patients ( P <0.05).There were no significant differences in the levels of Scr ,β2-MG and Alb in observation group between those in hospitalization time and those on 24 hours after heart failure ( P >0.05),however,there were significant differences in the levels of Cys-C between the two time points ( P <0.05).The incidence of all-cause mortality, incidence of cardiovascular events and secondary hospitalization rate in patients with high levels of Cys -C were significantly higher than those of patients with low levels of Cys-C ( P <0.05).Furthermore the levels of Scr [(114 ±61)μmol/L] in patients with cardiac function grade Ⅳwere significantly higher than those [(87 ±10)μmol/L] in control group ( P <0.05).Conclusion The levels of Cys-C are closely correlated to heart function ,which can reflect injury state of renal function of patients with acute heart failure at early period .The levels of Cys-C have important predictive significance for all-cause mortality ,incidence of cardiovascular events ,thus,which are regarded as a fast and reliable index in evaluating early renal injury of patients with heart failure .
Keywords：serum cystatin Curine protein markersacute heart failure
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2117-2119,2120 )