Effects of recombinant human brain natriuretic peptide on myocardial injury in patients with coronary heart disease after selective percutaneous coronary intervention
Abstract：Objective To investigate the effects of recombinant human brain natriuretic peptide ( rhBNP ) on myocardial injury in patients with coronary heart disease ( CHD ) after selective percutaneous coronary intervention ( PCI ) . Methods Two hundred and ten patients with CHD were randomly divided into rhBNP group ( n =106 ) and control group (n=104).The patients in both groups were treated by basic treatment , however, the patients in rhBNP group were given rhBNP on 2 hours before PCI , firstly which was intravenously injected at 1.5μg/kg loading dose for 90s, then continuously intravenously infused at 0.01μg· kg-1· min-1 for 72h.The serum levels of creatine kinase-MB (CK-MB),creatine cardiac troponin I( cTNI) ,N-terminal pro brain natriuretic peptide ( NT-proBNP ) and interleukin-8 ( IL-8 ) were detected before PCI and on 8h,24h,3d after PCI for both groups .Moreover,the changes of CK-MB,cTNI,NT-proBNP,IL-8 and the incidences of postoperative myocardial injury were observed and compared between two groups .Results There were no significant differences in the serum levels of CK-MB,cTNI,NT-proBNP,IL-8 before PCI between two groups ( P >0.05).The levels of CK-MB on 8h,24h after PCI in rhBNP group were significantly lower than those in control group ( P <0.05),and the levels of cTNI on 8h,24h,3d after PCI in rhBNP group were significantly lower than those in control group ( P <0.05).There were no significant differences in the serum levels of NT-proBNP,IL-8 before PCI between two groups ( P >0.05).The levels of NT-proBNP,IL-8 on 8h,24h,3d after PCI in rhBNP group were significantly lower than those in control group ( P <0.05). The incidences of postoperative myocardial injury in rhBNP group were significantly lower than those in control group ( P <0.05).Conclusion The administration of rhBNP before selective PCI may have a certain protective effects on postoperative myocardial injury by inhibiting activation of the sympathetic nerve -endocrine system and influencing inflammatory factors .
Keywords：coronary heart diseasepercutaneous coronary interventionmyocardial injuryrecombinant human brain natriuretic peptide
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2113-2116 )