Correlation between thymidine kinase 1 and malignant process of precancerous lesion of breast cancer

JIANG Xiaorong; WANG Yu; WANG Shasha

doi:10.3969/j.issn.1002-7386.2016.14.002

Abstract：Obj ectiev To investigate the correlation between thymidine kinase 1 ( TK1 ) and the process of precancerous lesion of breast cancer in order to evaluate the diagnostic accuracy and the utilization value of thymidine kinase 1 in the evaluation of malignant process of precancerous lesion of breast cancer .Methods The serum levels of TK1 were detected by using TK1 antibody in 3,442 female subjects, including 1,205 cases of mammary gland lesions (mammary gland lesion group) and 2,237 healthy subjects (control group),moreover, of whom 90 patients with precancerous lesions of breast cancer were followed up for 3 years to investigate the correlation between thymidine kinase 1 and the process of precancerous lesion of breast cancer ,furthermore , to evaluate the diagnostic accuracy of thymidine kinase 1 in precancerous lesions of breast cancer.Results There were significant differences in the average levels of TK 1 between control group and mammary gland lesion group ( P <0.05).Moreover, the incidence of precancerous lesion of breast cancer was not related with patient ’s age ( P >0.05).The levels of TK1 in patients with severe intraductal papilloma or atypical hyperplasia were significantly higher than those of patients with simple hyperplasia ( P <0.05).When TK1was 1.4pmol/L,the specificity in distinguishing benign lesion from malignant lesion of mammary glands was 89.5%,and sensitivity was 71.1%.After 6~36 months follow-up,in 90 cases of precancerous lesion of breast cancer ,the levels of TK1 in patients with precancerous lesion progression in secondary inspection were significantly increased ,as compared with those of patients in initial inspection ( P <0.05). Conclusion TK1 detection plays an important role in predicting the malignant process risk of precancerous lesions of breast cancer.