Effects of puerarin combined with telmisartan on adipocytokines, activity of renin angiotensin system and insulin resistance in patients with obesity-related hypertension
Abstract：Objective To investigate the effects of puerarin combined with telmisartan on adipocytokines , activity of renin-angiotensin system and insulin resistance in patients with obesity -related hypertension .Methods A total of 160 patients with obesity-related hypertension who were admitted and treated in our hospital from June 2013 to June 2015 were randomly divided into observation group ( n =80) and control group ( n =80).The patients in control group were treated by telmisartan,however,the patients in observation group were treated by puerarin combined with telmisartan ,with a treatment course of 1 month for both groups.After treatment,the body mass index (BMI), the ratio of waist vs hipratio (W/H), levels of adipocytokines (adiponectin, leptin and resistin), renin (PRA), angiotensin Ⅱ(AngⅡ), fasting plasma glucose (FBG), fasting insulin (FLns), homeostasis model insulin resistance index method (HOMA-IR) and insulin sensitivity index (ISI) were detected and compared between two groups .Results After the treatment,the BMI, W/H, leptin, resistin, PRA, AngⅡ, FBG, FLns and HOMA-IR in observation group were significantly decreased , as compared with those in control group,however ,the levels of adiponectin and ISI in observation group were significantly higher than those of control group (P<0.05).Conclusion Puerarin combined with telmisartan in treatment of obesity -related hypertension can effectively alleviate abdominal obesity , decrease BMI and W/H, regulate the levels of adipocytokines , inhibit the activation of renin-angiotensin system and improve insulin resistance .
Keywords：puerarintelmisartanobesity hypertensionadipocytokinesrenin-angiotensin systeminsulin resistance
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1970-1972,1973 )