Therapeutic effects of oral testosterone undecanoate on late onset hypogonadism in males and its effects on cardiovascular system

doi:10.3969/j.issn.1002-7386.2016.13.013

Abstract：Objective To observe the therapeutic effects of oral testosterone undecanoate on late onset hypogonadism ( LOH) in males and its effects on cardiovascular system .Methods Twenty-eight male patients with LOH were enrolled in the study.The patients were treated by oral testosterone undecanoate for 3 months.The AMS scoring,red blood cell count, packed red cell volume, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, mean arterial pressure,fasting blood glucose ,serum testosterone were detected before treatment , on 1 month and 3 months after treatment . Moreover the changes of these parameters were observed and compared before and after treatment .Results There were significant differences in AMS scoring ,serum levels of testosterone , red blood cell count , packed red cell volume , high density lipoprotein before treatment and on 1 month and 3 months after treatment ( P <0 .05 ) . There were significant differences in the levels of fasting blood glucose , mean arterial pressure, low density lipoprotein cholesterol before treatment and on 1 month and 3 months after treatment (P<0.05).The levels of triglyceride were significantly decreased on 3 months after treatment,as compared with those on 1 month after treatment ( P <0 ?.05),and the levels of total cholesterol were significantly decreasedon 3 months after treatment,as compared with those before treatment ( P <0.05). Conclusion The oral testosterone can obviously improve clinical symptoms of male patients with LOH , and long-term medication can decrease related parameters ,besides, AMS has certain value in evaluating male LOH .