Effects of drug intervention on gallbladder motor function in rabbit models with gallbladder stones after gallbladder- protected lithotomy
Abstract：Objective To observe the effects of ursodeoxycholic acid capsule on gallbladder motor function in rabbit models with gallbladder stones after gallbladder-protected lithotomy .Methods Sixty male New Zealand rabbits were enrolled as research subjects, firstly, the animal models with cholecystolithiasis were established , then, the rabbits underwent gallbladder-protected lithotomy under endoscope .According to different postoperative treatment modes , these rabbits were divided into three groups , with 20 rabbits in each group .The rabbits in control group were given general diet , the rabbits in model group were given the diet of resulting in calculus , the rabbits in intervention group were given diet of resulting in calculus +ursodeoxycholic acid .The gallbladder motor function ,the levels of cholecystokinin and somatostatin were detected in the three groups.Results After 3-week,5-week intervention,the fasting gallbladder volume, residual gallbladder volume, gallbladder volume and pressure in model group were significantly greater than those in control group , however , the largest gallbladder emptying rate was significantly lower than that in control group ( t =6.083~17.540, P <0.05).The fasting gallbladder volume, residual gallbladder volume , gallbladder volume and pressure in intervention group were less than those in model group,however, the largest gallbladder emptying rate was significantly higher than that in model group ( t =3.378~10.286, P <0.05).The contents of somatostatin in gallbladder tissues in model group were higher than those in control group,however,the contents of cholecystokinin were significantly lower than those in control group ( t =9.508~17.595, P <0.05).The contents of somatostatin in gallbladder tissues in intervention group were lower than those in model group ,however, the contents of cholecystokinin were significantly lower than those in model group ( t =5.433 ~16.462, P <0.05 ). Conclusion The ursodeoxycholic acid capsule intervention is helpful to regulate the synthesis of cholecystokinin and somatostatin,which can improve the gallbladder motor function after gallbladder-protected lithotomy.
Keywords：cholecystolithiasisgallbladder protected lithotomyursodeoxycholic acidgallbladder motor function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1960-1962 )