Therapeutic effects of percutaneous kyphoplasty combined with zoledronic acid injection on osteoporotic vertebral compression fracture

doi:10.3969/j.issn.1002-7386.2016.13.009

Abstract：Objective To observe the therapeutic effects of percutaneous kyphoplasty ( PKP ) combined with zoledronic acid injection on osteoporotic vertebral compression fracture (OVCF).Methods A retrospective analysis about 65 elderly patients with OVCF who underwent PKP was performed ,28 patients of whom were treated with PKP combined with zoledronic acid (group A),however,the other 37 patients were treated by PKP only ( group B).The visual analogue scale ( VAS) , activity of daily life ( ADL) , recurrence rate of compression fracture of vertabral body were observed and compared between two groups , following up at 1 week, 3 months,1 year,2 years after the operation .Moreover the risk factors influencing relapse rate of bone fracture after PKP were evaluated by multiple factor regression analysis .Results Both PKP and zoledronic acid could relieve the pains caused by OVCFs .After OVCFs, PKP could effective and quickly relieved the pains ,however, zoledronic acid could relieve the pains and keep the efficiency effectively .There was no significant difference in the recurrence rate of compression fracture of vertabral body at 1 year after operation between group A and group B ( P >0.05).However the recurrence rate at 2 years after operation in group A was significantly lower than that in group B ( P <0.05).The multiple factor regression analysis showed that the recurrence of bone fracture after operation was correlated to patient ’ s body mass index (BMI), bone mineral density,bone cement volume,application of zoledronic acid,however,which was not related with patient’s age,sex, leakage state of bone cement , position of vertebral fracture and recovery degree of vertebral fracture anterior border.Conclusion PKP combined with zoledronic acid injection in treatment of OVCF can relieve patient ’ s pain, improve life quality ,meanwhile ,which is an effective protective measure to decrease recurrence of vertebral body fracture .