Correlation betw een plasma Omentin-1 levels and coronary heart disease
ZHAO Peng
WANG Weiwei
SONG Zhijing
Abstract：Objective To investigate the correlation between plasma Omentin -1 (OE-1 ) levels and coronary heart disease ( CHD) .Met hods One hundred and eight patients who underwent coronary angiography examination from January to July 2015 were enrolled in the study,including 78 cases of CHD and 30 cases non-CHD ( control group) ,among 78 patients with CHD,there were 34 cases of stable angina pectoris ( SAP group) and 44 cases of unstable angina pectoris ( UAP group) . The plasma levels of Omentin-1 were detected by ELISA,finally, the results were analyzed and compared among three groups. Results The plasma levels of OE-1 in SAP group and UAP group were significantly lower than those in control group, and Gensini scores were significantly higher than those in control group ( P <00.5).However there were no significant differences in plasma levels of OE-1and Gensini scores between SAP group UAP group ( P >0.05 ) .The plasma levels of OE-1 were negatively correlated to BMI ( r =0.027, P <0.05).The results by multiple factor logistic regression analysis showed that SBP,TC,LDL,HDL-C-C,OE-1 levels and Gensini scores were independent risk factor of CHD ( P <0.05).Conclusion The decrease of plasma levels of OE-1 in patients with CHD is associated with pathogenesis of CHD,which may provide an new target for intervention with the occurrence and development of CHD development.
Keywords：coronary heart diseaseOmentin-1correlation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1303-1305 )