Dynamic observation on the changes of BMP-7,BMP-2 and VEGF during fracture healing in diabetic rat models
TANG Zhouzhou
XU Yongtao
MA Liang
Abstract：Objective To observe dynamically the changes of vascular endothelial growth factor ( VEGF ) , bone morphogenetic protein-2 ( BMP-2) and bone morphogenetic protein-7 ( BMP-7) during fracture healing in diabetic rats,and to explore the mechanism of affecting fracture healing in diabetic rats.Methods Seventy Wistar male rats were selected in the study,according to random digits table these rats were divided into diabetes group ( n =35) in which the rats were injected intraperitoneally with streptozotocin ( STZ) to establish diabetes models, and the other 35 rats were served as control group. The left tibias of rats in both groups were sawn to break, then were treated by external fixation reduction.The changes of expression levels of VEGF,BMP-2,BMP-7 in serum and bony callus were detected and observed on 1w,3w,5w,7 w after operation.Results The expression levels of BMP-7, BMP-2 and VEGF in bony callus of diabetes group were significantly lower than those in control group on 1w,3w after operation ( P <0.05),however, there were no significant differences in the expression levels of VEGF,BMP-2,BMP-7 in bony callus on 5w,7w after operation between two groups ( P >0.05).There were no significant differences in the serum levels of VEGF,BMP-7,BMP-7 from the first week to the seventh week after operation between two groups ( P >0.05),except that the expression levels of BMP-7 in diabetes group on 1w,3w after operation were significantly lower than those in control group ( P >0.05).Conclusion The decrease of expression levels of BMP-7,BMP-2,VEGF in serum and bone callus of diabetic rats may be an important cause of delayed healing.
Keywords：diabetes mellitusfracturevascular endothelial growth factorBMP-2BMP-7
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1297-1299 )