Diagnostic value of MDIG in differential diagnosis between benign and malignant hydrothoraxs
WEI Zemin
ZHAO Hongwen
Abstract：Objective To investigate the clinical significance and diagnostic value of MDIG protein , combined with CEA and LDH, in differential diagnosis between benign and malignant hydrothoraxs .Methods The cell counts, lymphocyte proportion ,the levels of total protein,MDIG protein,CEA and LDH were detected by ELISA in 36 patients with malignant hydrothorax ( malignant hydrothorax group ) and 39 patients with tuberculous hydrothorax ( tuberculous hydrothorax group ) . Results The patient’ s age, the levels of MDIG protein and CEA in malignant hydrothorax group were significantly higher than those in tuberculous hydrothorax group ( P <0.05 ), and the detection sensitivity was 93.1%, 69%, 82.8%, respectively and detection specificity was 79.5%, 82.1%, 97.4%, respectively.However the sensitivity and specificity of combined detection were 97.2% and 99.9%,respectively.The total protein levels and lymphocyte proportion in tuberculous hydrothoraxs group were significantly higher than those in malignant hydrothorax group ( P <0.05), and detection sensitivity was 84.6%, 94.9%, respectively and detection specificity was 89.7%, 51.7%, respectively.However the sensitivity and specificity of combined detection were 99.2%and 95.0%,respectively.Conclusion MDIG protein plays an important role in the diagnosis of malignant hydrothoraxs .The patient’ s age,MDIG protein and CEA have important clinical significance in diagnosis of malignant pleural effusion ,furthermore, lymphocyte proportion and total protein levels are of important clinical significance in the diagnosis of tuberculous hydrothoraxs .
Keywords：CEALDHMDIGmalignant hydrothoraxstuberculous hydrothoraxs
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 979-981 )