Therapeutic effects and safety of 3DCRT combined with capecitabine on advanced rectal cancer

doi:10.3969/j.issn.1002-7386.2016.07.003

Abstract：Objective To investigate the therapeutic effects and safety of three dimensional conformal radiation therapy (3DCRT) combined with capecitabine chemotherapy on rectal cancer at stage Ⅱ and Ⅲ.Methods The data about 50 patients with rectal cancer at stage Ⅱ and Ⅲ who underwent radical resection of rectal carcinoma in Department of Oncology of our hospital from November 2008 to November 2011 were retrospectively analyzed .According to the therapeutic way after operation, these patients were divided into simple radiotherapy group (3DCRT only, n =18) and synchronization chemoradiotherapy group (3DCRT+capecitabine, n =32).The therapeutic effects, patient’s survival state and incidence of adverse reactions were observed and compared between the two groups .Results There were no significant differences in 3-year overall survival rate (90.6%vs 72.2%, P >0.05) and the disease free survival rate (75.0%vs 61.1%, P >0.05) between two groups .The local recurrence rates in synchronization chemoradiotherapy group were significantly lower than those in simple radiotherapy group ( P <0.05).The incidences of hand-foot syndrome, bone marrow depression and diarrhea in synchronization chemoradiotherapy group were significantly higher than those in simple radiotherapy group ( P <0.05 ) . However there were no significant differences in the incidences of genitourinary tract reaction and vomit between two groups (P>0.05).Conclusion 3DCRT combined with capecitabine has better therapeutic effects and lower local recurrence rates in treatment of rectal cancer at stage ⅡandⅢ,though the incidences of acute adverse reactions are increased at some extent , which are tolerable .