Experimental study on the antidepressant-like activity of xylocarpin H-a limonoid from Xylocarpus granatum

doi:10.3969/j.issn.1002-7386.2016.07.001

Abstract：Objective To investigate the antidepressant-like activity of xylocarpin H , a limonoid from Xylocarpus granatum.Methods The forced swimming test (FST) and tail suspension test (TST) were used to detect the antidepressant-like activity of xylocarpin H , open field test ( OFT) was performed to evaluate the anxiolytic activity of xylocarpin H in mice . Results The results showed that 7-day continuous administration with xylocarpin H by intragastric gavage decreased significantly the floating time in FST,which in blank control group , xylocarpin H medication administration groups (5mg/kg, 15mg/kg,50mg/kg),venlafaxine medication administration group was (123 ±5)s,(110 ±11)s,(105 ±6)s,(97 ±6)s,(99 ± 7)s,respectively.Moreover 7-day continuous administration with xylocarpin H by intragastric gavage decreased obviously the immobility time in TST,which in the five groups as mentioned above was (125 ±7)s,(109 ±10)s,(103 ±8)s,(100 ±6)s, (94 ±8)s,respectively,besides,7d xylocarpin H continuous administration with xylocarpin H by intragastric gavage decreased significantly the residence time in central zone of OFT ,which in the five groups was (25 ±3)s,(39 ±5)s,(45 ±9)s,(46 ± 3)s,(43 ±7) s,respectively.However xylocarpin H had no effects on spontaneous activity of mice .Conclusion The xylocarpin H has obvious antidepressant-like and anxiolytic activities , which may provide an experimental basis for research and development of new antidepressants .