Experimental study of the effects of pentoxifylline on microcirculation of intestinal mucosa in rats with severe acute panreatitis
Abstract：Objective To investigate the effects and significance of pentoxifylline ( PTX) on microcirculation of intestinal mucosa in rats with severe acute panreatitis (SAP).Methods A total of 96 SD rats were randomly divided into 3 groups: shame-operation (SO) group,SAP model group,PTX treatment group.After the animal models with SAP were established, the ascites amount, pancreatic pathological changes , micrangium caliber and velocity of intestinal mucosa were observed at 2h,6h,12h,24h after operation, moreover,the levels of plasma LPS,serum AMY and LIP were detected for the three groups .Results There were significant differences in ascites amount , pancreatic pathological scores at the four time points between SAP group and SO group as well as between PTX group and SAP group ( P <0.05).As compared with those in SO group, micrangium caliber and velocity of intestinal mucosa were significantly decreased in SAP group and PTX group (P<0.05).The levels of LPS,AMY,LIP in SAP and PTX group were significantly higher than those in SO group ( P <0.05).Conclusion PTX can effectively improve microcirculation of intestinal mucosa in rats with SAP .
Keywords：severe acute pancreatitisintestinal injurymicrocirculationpentoxifyllinerats
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 808-811 )