Study on the inhibitory effects of curcumin combined with sorafenib on the proliferation of human renal carcinoma cell line-786-O in vitro
Abstract：Objective To explore the effects of curcumin combined with sorafenib on the proliferation of human renal carcinoma cell line-786-O in vitro. Methods The inhibitory effects of curcumin and sorafenib on growth of renal carcinoma cell line - 786-O were detected by MTT. Results The curcumin and sorafenib inhibited the proliferation of human renal carcinoma cell line - 786-O in a concentration and time-dependent manner,their IC50 was 29. 2μmol/ L,6. 5μmol/ ml on 48 hours,respectively. The combined inhibitory effects of curcumin at concentration of 6. 25μmol/ L,12. 5μmol/ L,25μmol/ L, 50μmol/ L and sorafenib at concentration of 1. 5μmol/ L,3μmol/ L,6μmol/ L,12μmol/ L for 24h,48h,72h were significantly higher than those of single application of curcumin or single application of sorafenib( P ﹤ 0. 05). Conclusion Curcumin can significantly inbibit the growth of 786-O cells,which can increase the sensitivity of 786-O cells to sorafenib.
Keywords：curcuminsorafenibdrug therapycombination786-Orenal cancer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 495-498 )