Expression and significance of S100P,CD147 and OCT4 in different stages of TNM of gastric cancer

LI Bing; LUO Liling; LAI Danian

doi:10.3969/j.issn.1002-7386.2016.04.003

Abstract：Objective To investigate the expression and significance of S100P,CD147 and OCT4 in different stages of TNM of gastric cancer. Methods The expression levels of S100P,CD147 and OCT4 were detected by immunohistochemistry in 54 cases of gastric cancer,40 cases of chronic gastritis and 20 cases of normal gastric tissues,and the expression levels in different stages of TNM of gastric cancer were observed and compared. Results The positive expression rate(18. 52℅ )of S100P in gastric cancer tissues was significantly lower than that in normal gastric tissues and chronic gastritis tissues( P ﹤ 0. 05),however,the positive expression rates(100℅ )of CD147 and OCT4(77. 38℅ )were significantly higher than those in normal tissues and chronic gastritis tissues( P ﹤ 0. 05). The positive rate(0)of S100P in stage Ⅴ was significantly lower than that in stage I(37. 50℅ )and in stage Ⅱ(35. 71℅ )( P ﹤ 0. 05). The positive rates of CD147 in different stages of TNM were all 100℅ ,in which the strong positive rate was significantly higher than weak positive rate and moderate positive rate( P ﹤ 0. 05). The positive rate of OCT4 in stage Ⅲ and in stage Ⅴ was significantly higher than that in stageⅠ( P ﹤ 0. 05). The positive expression rate of S100P in patients with distant metastasis was significantly lower than that of patients without distant metastasis( P ﹤ 0. 05),however,the positive expression rate of OCT4 in patients with distant metastasis was significantly higher than that of patients without distant metastasis( P ﹤ 0. 05). There were no significant differences in positive expression rates of S100P,CD147,OCT4 in patients with different differentiation degrees (P ﹥ 0. 05). Conclusion The expression levels of S100P in gastric tissues are significantly decreased,however,the expression levels of OCT4 and CD147 are significantly increased,which is closely correlated to TNM staging and distant metastasis of patients with gastric cancer,but which is not related with tumor’s differentiation degree.