Liver protective and antioxidative effect of Jiangsu Baishouwu C21 steroidal glycosides in Hyperlipidemia Rats
Abstract：Objective To study the effect of Jiangsu Baishouwu C21 steroidal glycosides on experimental hyperlipidemia rat liver function and lipid peroxidation. Methods to establish a rat model of experimental hyperlipidemia,on hyperlipidemia rats were given Baishouwu C21 steroidal(20mg/ kg,40mg/ kg),atorvastatin calcium 10mg/ kg and 1%sodium carboxymethyl cellulose solution orally,1 times a day,for 2 weeks,and normal the control group. Comparison of the changes of body weight,liver coefficient calculation;serum alanine aminotransferase and liver test( ALT),aspartate aminotransferase(AST);liver pathology. Parallel serum superoxide dismutase( SOD),malondialdehyde( MDA) and glutathione peroxidase( GSH-Px ) detection. Results the C21 steroidal drugs for 2 weeks,the liver coefficient of hyperlipidemia model can effectively control rats,pathological section showed that it can improve the hepatic steatosis. Cynanchumbungei high dose group could decrease hyperlipemia rats SOD and GSH-Px levels,the treatment group can significantly reduce the content of MDA in hyperlipemia rats increased. Conclusion Baishouwu C21 steroidal glycosides can improve hyperlipidemia rats liver function,to reduce lipid peroxidation in hyperlipidemia rats.
Keywords：C21 steroidalliver functionliver pathologylipid peroxidation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 335-337 )