The diagnostic value of combination dectection of CRP with Cys C for early renal function injury in patients with gout

ZHENG Chuangshi; QIU Zhaoyu

doi:10.3969/j.issn.1002-7386.2016.02.006

Abstract：Objective To investigate the diagnostic value of combination dectection of serum C reactive protein (CRP)with Cystatin C(Cys C)for early renal function injury in patients with gout. Methods The data of 151 patients with gout in our hospital from July 2011 to July 2014 were retrospectively analyzed. According to glomerular filtration rate(GFR), these patients were divided into renal injury group(60ml/ min < GFR < 90ml/ min)( n = 59)and non injury group (90ml/ min = GFR < 90)( n = 92),the differences of CRP,Cys C,GFR,β2-MG,urine microglobulin( β2-MG),urinary albumin(mAlb),uric acid(UA)were compared between two groups. Results There were significant differences in CRP, Cys C,GFR,β2-MG,mAlb,UA,GFR between renal injury group and non injury group( P < 0. 05). The diagnosis sensitivity by CRP was 62. 71% ,specificity 84. 78% ,misdiagnosis rate 15. 22% ,omission diagnose rate 35. 28% ,positive predictive value 78% ,negative predictive value 72. 55% ,and the diagnosis sensitivity by Cys C was 57. 63% ,specificity 77. 17% , misdiagnosis rate 22. 83% ,omission diagnose rate 41. 37% ,positive predictive value 61. 82% ,negative predictive value 73. 96% ,however,the diagnosis sensitivity by Cys C + CRP was 86. 44% ,specificity 86. 96% ,misdiagnosis rate 13. 04% , omission diagnose rate 13. 55% ,positive predictive value 80. 95% ,negative predictive value 90. 91% ,and the area under ROC curve of AUC was 0. 908. Conclusion The levels of CRP and Cys C in patients with gout complicated by renal function injury are obviously increased,thus the combinationn detection of CRP with Cys C can enhance the diagnostic value for early renal function injury in patients with gout.