The correlation between thyroid function abnormality and gestational diabetes mellitus as well as gestational hypertension at different pregnant periods
Abstract：Objective To investigate correlation between thyroid function abnormality and gestational diabetes mellitus as well as gestational hypertension at different pregnant periods. Methods The clinical data of 480 pregnant women were retrospectively analyzed in which 96 cases of gestational diabetes were served as diabetes group,52 cases of gestational hypertension were served as hypertension group,and 332 normal pregnant women were regarded as control group. The levels of free thyroxine( FT4)and thyroid stimulating hormone( TSH)of pregnant women in the three groups were statistically analyzed,and the levels and change trend of FT4 and TSH at early gestation,mid-gestation,late-gestation were analyzed and compared among groups. Furthermore different kinds of abnormal thyroid function abnormalities were statistically analyzed. Results The FH4 levels at mid-gestation in diabetes group and hypertension group were significantly lower than those in control group( P ﹤ 0. 05),moreover,the decrease rate of FT4 at mid-gestation in diabetes group was significantly higher than that in control group( P ﹤ 0. 05). The levels of TSH at mid-gestation in diabetes group were significantly higher than that in control group( P ﹤ 0. 05). However the levels of TSH at late-gestation in diabetes group and hypertension group were significantly higher than those in control group( P ﹤ 0. 05). With the pregnant duration went on,there was a increase trend in TSH levels,but there was no significant difference in increasing degree among the three groups( P ﹥ 0. 05). There were no significant differences in integrating incidence rates of clinical hyperthyroidism, clinical hypothyroidism,sub-clinical hyperthyroidism at late-gestation among three groups( P ﹥ 0. 05). However integrating incidence rates of sub-clinical hypothyroidism in diabetes group and hypertension group were significantly higher than those in control group( P ﹤ 0. 05), moreover,integrating incidence rates of low T4emia in diabetes group and hypertension group were significantly higher than those in control group( P ﹤ 0. 05). At late-gestation,the incidence rates of mild thyroid dysfunction in diabetes group were significantly higher than those in control group( P ﹤ 0. 05),however,there were no significant differences between diabetes group and control group( P ﹥ 0. 05). Conclusion As compared with normal pregnant women,the patients with gestational hypertension or gestational diabetes have higher levels of TSH,lower levels of FT4 and higher incidence rates of mild thyroid dysfunction. Therefore,we should pay much attention to the detection of thyroid function of these patients.
Keywords：different pregnant periodsgestational diabetesgestational hypertensionthyroid function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 20-23 )