Expression recognition and 5-HTTLPR,5-HT6,Neurexin,Neuroligin gene polymorphism in children with autism

doi:10.3969/j.issn.1002-7386.2016.01.002

Abstract：Objective To investigate the expression recognition of children with autism and 5-HTTLPR,5-HT6, Neurexin,Neuroligin gene polymorphism. Methods A total of 60 children with autism who visited Department of Child Psychology of Kangning Hospital were regarded as observation group,and the other 60 children selected in different kindergartens in Shenzhen city were served as control group. The correlation between expression recognition abilities of these children and 5-HTTLPR,5-HT6,Neurexin,Neuroligin gen polymorphism was analyzed and compared between two groups. Results There was no significant difference in PrN170 between two groups( P ﹥ 0. 05). As compared with that in control group,P300 incubation period in observation group was significantly prolonged( P ﹤ 0. 01),however,the P300 amplitude in observation group was significantly decreased( P ﹤ 0. 01). There was a significantly difference in 5-HTTLPR genotype between two groups( P ﹤ 0. 05). However there was no significantly difference in 5-HT6 gene polymorphism( P ﹥ 0. 05), nor was in Neuroligin gene polymorphism between two groups( P ﹥ 0. 05). Conclusion The physiological indexes related with expression recognition of children with autism are different from those of healthy children,moreover,the genotypes of 5-HTTLPR and Neurexin in children with autism are also different from those of healthy children.