Effects of sodiu m tanshinone ⅡA sulfonate combined with atorvastatin on heart function, oxidative stress and vascular endothelial function of patients with coronary heart diseases
Abstract：Objective To observe the effects of sodium tanshinoneⅡA sulfonate combined with atorvastatin on heart function, oxidative stress and vascular endothelial function of patients with coronary heart diseases ( CHD) in order to explore the possible action mechanism of sodium tanshinoneⅡA sulfonate in the treatment of CHD.Methods One hundred and sixty patients with CHD who were diagnosed and treated in our hospital from January 2014 to January 2015 were randomly divided into control group and observation group,with 80 patients in each group.The patients in control group,on the basis of routine therapy, were given atorvastatin,however,the patients in observation group,on the basis of control group,were given sodium tanshinoneⅡA sulfonate,with a treatment course of 30 days for both groups.The changes of LVEF,LVESD,LVEDD,FMD, NMD,SOD,MDA,NO,ET-1,TXB2,6-Keto-PGF1a,vWF and VEGF levels were observed before and after treatment in both groups.Results As compared with those before treatment,the levels of LVEF,FMD,NMD,SOD,NO,6-keto-PGF1a and VEGF were significantly increased after treatment,however, the levels of LVESD,LVEDD,MDA,ET-1,TXB2 and vWF were significantly decreased in both groups ( P <0.05).Moreover the improvement degree in observation group was more obvious than that of control group ( P <0.05).Conclusion Sodium tanshinone ⅡA sulfonate combined with atorvastatin can significantly improve cardiac function of patients with CHD,and its action mechanism may be correlated to restraining oxidative stress and improving vascular endothelial function of patients with CHD.
Keywords：sodium tanshinone ⅡA sulfonateatorvastatincoronary artery diseasescardiac functionoxidative stressvascular endothelial function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3695-3698 )