Expression and clinical significance of TH4 and CD133 in epithelial ovarian cancer
LU Dongmei
YANG Junhong
Abstract：Objective To explore the expression and clinical significance of HE4 and CD133 in epithelial ovarian cancer ( EOC) .Methods The expression levels of HE4 and CD133 protein were detected in 57 cases of EOC tissues ( EOC group) and 19 cases of normal ovarian tissues ( control group ) by immunohistochemistry.The correlation between the expressions of TH4 ,CD133 and clinicopathological parameters was analyzed.Results The positive expression rates of HE4 in control group and in EOC group were 42.1%(8/19),71.9% (41/57),respectively,and the positive expression rates of CD133 in the two groups were 31.6%(6/19),68.4%(34/57),respectively,there were significant differences between two groups ( P <0.05 ).The expressions of HE4 and CD133 were closely correlated to clinical pathological staging, histodifferentiation degree, menopausal state, lymph node metastasis ( P <0.05) .Spearman correlation analysis showed that the expression of HE4 was closely related to that of CD133 ( r =0.340, P <0.01).Conclusion The overexpression of HE4 and CD133 protein may be correlated to the pathogenesis and development of EOC.
Keywords：epithelial ovarian cancerHE4CD133immunohistochemistry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3538-3540 )