Effects of atorvastatin on the transient outward potassium current of cardiocytes after acute myocardial infarction in rabbits
Abstract：Objective To investigate the change of transient outward current ( Ito ) of cardiocytes in infarcted marginal zone (AMI-R) and noninfarcted zone (AMI-N) after acute myocardial infarction in rabbits (AMI),and to observe the effects of atorvastatin on Ito.Methods Thirty female big ear white rabbits were randomly divided into 3 groups:control group,AMI group and atorvastatin group,with 10 rabbits in each group.After AMI animal models were established, the rabbits in atorvastatin group were given atorvastatin orally for 7 days (5mg· kg-1· d-1),then single ventricular myocardium cell was separated by enzymolysis method,finally, the Ito density of epicardium ( Epi) in AMI-R and AMI-N was recorded by whole cells patch clamp technology.Results The Ito density of epicardium (Epi) cells reached peak at +70mV voltage in control group and AMI group.There was a significant difference in the electric current density of AMI group between AMI-R and AMI-N ( P <0.01).There was no significant difference in inactivation curve trend between AMI-R and AMI-N in control group and AMI group,however, there was a significant difference in half inactivation voltage in AMI-R between control group and AMI group ( P <0.05).Conclusion There exists variability in Ito density of Epi cells in AMI-R and AMI-N,as compared with that in normal myocardial cells,and atorvastatin can improve the abnormal Ito density in AMI-R and AMI-N after AMI.
Keywords：atorvastatinmyocardial infarctionpatch clamp technologytransient outward current
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3369-3371 )